WICKED SUPPLEMENTS CYCLE GUARD 90CAPS
$59.95
CYCLE GUARD
- Reduce androgen and drug related toxicity
- Support optimal liver health and bile flow
- High potency blend of liver protective ingredients
- Ideal for people exposed to environmental toxins or liver toxic oral androgens
Soon after taking oral androgens it becomes apparent that excessive doses or prolonged use can be damaging to liver function, (14) and since there have been several case studies of jaundice and liver failure secondary to oral androgen use, both self-administered (15) and in a clinical setting. (16,17) The liver toxic effects of oral androgens are of a primarily cholestatic nature(liver damaging). This leads to impaired bile flow at low concentrations. These retained bile salts cause programmed cell death and at higher concentrations, necrosis and severe liver damage.
It was designed with users of oral androgens in mind, and brings together the best anti-cholestatic ingredients available. Each ingredient in Cycle Guard has been specifically chosen to help combat the effects of oral androgens on the liver.
- Can prevent programmed cell death and strongly stabilizes mitochondrial membranes (1)
- When used consistently, TUDCA eventually becomes the predominant bile acid in the liver and in general circulation. (2)
- Directly stimulates bile export and secretion which helps digestion, cleansing of toxins and hormone production (3,4,5)
- Stabilizes cellular membranes and dilates bile canaliculi (fine tubular channels forming a three-dimensional network within the parenchyma of the liver. They join to form the bile ductiles and eventually the hepatic duct.) This has been shown to protect human cells from accumulation of toxic bile salts within the hepatocyte (A hepatocyte is a cell of the main tissue of the liver. Heptocytes make up 70-85% of the liver's cytoplasmic mass) An accumulation of toxic bile salts can cause serious liver damage (6,7)
- Oral androgen administration may decrease liver values all of which may be restored, and even raised, by the use of PPC (polyenylphosphatidylcholine) (8)
- PPC is secreted into bile by hepatocytes, where it serves as a major component of the micelles in which bile acids are emulsified. Increased levels of phosphatidylcholine reduces the toxicity of bile acids (9)
- Is both a metabolite of and a precursor to glutathione, a naturally-occurring peptide that is important in the detoxification of lipophilic toxins in the liver. (10)
- Functions as an anti-oxidant to minimise oxidative stress to cells caused by reactive oxygen species (11)
- Has anti-inflammatory properties and may reduce levels of inflammatory cytokines. (12)
- May minimise muscle fatigue during exercise (13)
- Is a precursor to glutathione, which may be able to prevent androgen induced cholestasis and liver injury.
- Can inhibit bile acid induced hepatocyte programmed cell death, (18,19,20) reduces the inflammatory cytokine TNF-alpha, (21,22) and can reduce oxidative stress via glutathione replenishment, (23) which may also play a role in treating the effects of cholestasis (liver damage). (24)
- Has been studied extensively as a safe and effective treatment for pregnancy induced cholestasis (liver damage) (25,26,27) and in a case study, was even shown to reverse severe androgen induced cholestasis. (28) Due to its distinct mechanism of action it has an additive effect when used alongside TUDCA. (18,26)
- As a direct precursor to glutathione the benefits associated with SAMe use are not limited to liver protection. It is also in wide use as a general antioxidant and anti-inflammatory.
Tauroursodeoxycholic Acid (TUDCA) 125mg*
Polyenylphosphatidylcholine (PPC) 450mg*
N-Acetyl Cysteine (NAC) 600mg *
S-Adenosyl-L-Methionine Disulfate Tosylate (SAMe) 200mg*
Store in a dry cool place away from light.
